Scientists in Ireland have discovered a mechanism that could explain why smokers are more likely to contract tuberculosis (TB) or experience complications with the disease.
The study, published in the American Journal of Respiratory and Critical Care Medicine, involved smokers, ex-smokers and non-smokers. Cells were taken from the lungs of all participants using a bronchoscopy. In the laboratory, the researchers assessed what happened to the cells when infected with the bacterium that causes TB.
The researchers found that the white blood, or immune, cells from the lungs of smokers and ex-smokers were more susceptible to the TB infection upon contact with it than that of non-smokers. They discovered that this was because damage to these cells had rendered them unable to fight the bacteria, giving way to infection.
These findings could be used to improve TB control methods, as well as in the development of new treatments and vaccines for the disease.
Read the abstract of the journal article.
Read the ELF factsheet on bronchoscopies (English).
Factsheets in a variety of languages and on a range of topics, including bronchoscopy, are also available.
Learn about the conditions that can affect our lungs and access our lung condition specific information.Read more
Learn more about life with a lung condition and things you can do to improve your quality of life.Read more
Learn about the factors that can cause lung disease and the ways to reduce your contact with them.Read more
Sign up to our free monthly newsletter to get the latest information and research news on lung conditions, plus views from experts and patients! You can unsubscribe at any time.