Lung cancer screening Print

Lung cancer screening

Lung cancer screening is the process of using tests to find the disease at an early stage, before symptoms are present.

Unlike other cancers, routine screening for lung cancer is not common across the world. However, research has found that lung cancer screening can improve survival rates. Many health organisations are calling on governments and international organisations to start offering programmes to people considered to be high-risk.

This factsheet looks at what lung cancer screening is, the risks and benefits of screening and the current position of health organisations.

Last Update 24/05/2021
This content is available in multiple languages.

Overview


Lung cancer is the biggest cancer killer in Europe; it causes more deaths than colon, breast and prostate cancers combined. When lung cancer is detected based on symptoms, the disease is mostly at a late stage, making treatment much less effective. Screening can detect cancer at a much earlier stage. Finding cancer earlier means that treatments can work better and even cure lung cancer, improving the outcomes for people living with the disease and reducing medical costs.

What does lung cancer screening involve?


There are several tests that can look at how healthy our lungs are. The test that is seen as most effective for finding lung cancer at an early stage is known as a low-dose CT (Computed Tomography) scan. It uses x-ray and computer technology to take multiple pictures of the chest. A computer combines these images to produce detailed pictures of your lungs. These images are more detailed than regular chest x-rays.

A screening programme involves routinely checking certain groups of people at regular intervals. These kinds of programmes exist in many countries for other cancers, such as breast or cervical cancer, where screening is routinely offered to women in a certain age group.

What happens during a low-dose CT scan?


How does the chest CT scan detect lung cancer?


What are the benefits of screening programmes?


When lung cancer is detected based on symptoms – such as a long-term cough and repeated chest infections – the lung cancer is likely to already be at a late stage. There are fewer treatment options available the later lung cancer is detected. Finding cancer sooner can help increase the chance of cancer treatments being effective – helping people live longer and improving quality of life. 3

Screening programmes can help find lung cancer much earlier. Research suggests that using low-dose CT scans is up to four times more likely to pick up an early tumour compared to a traditional chest x-ray.

“ERS, advocates for the earliest detection and screening of lung cancer. Lung cancer still remains the largest killer among cancers. Rolling out programmes for low dose CT screening of high risk individuals (former or current smokers) could save lives and help change this devasting curve.”

Arzu Yorgancioğlu, ERS Advocacy Council Chair

Evidence also suggests that screening programmes can help reduce the number of deaths from lung cancer:

Results from the largest trial looking at lung cancer screening were published in 2011. They found that using low-dose CT scans to screen for lung cancer could reduce the number of deaths by 20% compared to chest x-rays.1

The second largest trial to date was conducted in Belgium and Holland with results published in 2020. It found that lung cancer deaths were reduced by 24% after 10 years when low-dose CT scans were offered to men at high-risk of lung cancer.2

Screening programmes can also identify other issues– such as chronic obstructive pulmonary disease (COPD) or heart disease. If these issues are found, they will be followed up.

“I am very supportive of targeted screening programmes. It is so important to roll out targeted screening in the way we currently offer for other conditions so people can understand the benefits – for example regular eye checks and diabetic eye tests for specific risks.”

Janette, UK, lung cancer survivor and patient advocate

Are there any risks of screening programmes?


Screening programmes are not perfect and there are some risks involved. To minimise these risks, screening programmes are only offered to people who are considered at a high risk of the disease.

Low-dose of radiation

All x-rays use small amounts of radiation during the process of scanning. The dosage is 90% lower with a low-dose CT scan compared to a traditional chest CT scan. There is still some radiation exposure, which can cause cancer in a very small number of cases. The amount is equivalent to the radiation a person is exposed to on average over 6 months through the natural environment or equivalent to 15 traditional chest x-rays.

Getting the wrong result

Although it is rare, tests can sometimes give the wrong results, indicating a person has lung cancer when they do not. This can happen for a variety of reasons, for example if a person is experiencing an infection at the time of a scan. This is called a false-positive result. This result is usually followed up with more tests, which may cause stress and anxiety.

Treating a cancer that may have been harmless

Sometimes cases of lung cancer are detected that may grow very slowly and are less harmful in comparison to other types. Again, you could be sent for more tests and treatment that may not have been needed. This is called overdiagnosis. It is important to discuss with your doctor the risks and benefits of tests and potential treatments based on any other health problems you may have. This will help you to reach an informed decision on how to proceed.

Over the last 20 years, research has focused on understanding more about the lung nodules that are detected on CT scans. There are several guidelines that help healthcare professionals to identify lung nodules and therefore manage the next steps after they have been seen on a scan. Multidisciplinary teams of specialised respiratory doctors and chest radiologists are required to help work on finding and managing any abnormalities that are found. This has helped to greatly reduce the risks linked with screening to ensure that only the nodules that are cancer are being treated.

What is a national screening programme?


A national screening programme involves finding groups of people who are considered most at-risk of lung cancer and offering lung screening appointments.

“There is work still to do to decide which people would receive screening but whichever group it is, the benefits of detecting lung cancer earlier are huge and could save lives.”

Janette, UK, lung cancer survivor and patient advocate

Is there a screening programme available in my country?


To date, the USA and China are the only countries that offer people the option of screening for lung cancer. This is covered by the national health systems in these countries. Countries such as the Netherlands and the UK offer screening in some locations.

It is the job of health authorities and screening councils to balance the risks and harms and develop robust and effective screening programmes.

What does the future hold?


Further reading


The European Lung Foundation (ELF) was founded by the European Respiratory Society (ERS), with the aim of bringing together patients, the public and respiratory professionals to positively influence respiratory medicine. ELF is dedicated to lung health throughout Europe, and draws together the leading European medical experts to provide patient information and raise public awareness about lung disease.

This material was compiled with the help of Janette Rawlinson, ELF Patient advisory group member, Dr Georgia Hardavella (Respiratory Consultant) and Dr Nikolaos I. Kanellakis (Postdoctoral Researcher). This factsheet has been endorsed by Lung Cancer Europea (LuCE).
Produced in February 2021.
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